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Progress on molecular biomarkers and classification of malignant gliomas
Chuanbao Zhang, Zhaoshi Bao, Wei Zhang, Tao Jiang
Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 150-156 doi: 10.1007/s11684-013-0267-1
Keywords: malignant glioma molecular biomarker IDH1 MGMT molecular classification
Pengming SUN PhD, MD , Jalid SEHOULI PhD, MD , Lihui WEI BM ,
Frontiers of Medicine 2009, Volume 3, Issue 3, Pages 256-264 doi: 10.1007/s11684-009-0052-3
Keywords: target therapy gynecologic malignant tumors clinical trail molecular medicine
Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma
Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 240-262 doi: 10.1007/s11684-022-0936-z
Keywords: glioma progression molecular classification EM/PM subtyping intratumor heterogeneity
Frontiers of Medicine doi: 10.1007/s11684-023-1017-7
Keywords: single-cell RNA-seq glioma radial glia primitive oligodendrocyte precursor cell immune escape
RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway
Frontiers of Medicine 2023, Volume 17, Issue 1, Pages 143-155 doi: 10.1007/s11684-022-0929-y
Keywords: RGS16 let-7c-5p glioma proliferation migration
Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang
Frontiers of Medicine 2021, Volume 15, Issue 4, Pages 551-561 doi: 10.1007/s11684-020-0760-2
Keywords: glioma evolution mechanism strategies tumor heterogeneity secondary glioma
R. Lyle Hood,Rudy T. Andriani,Tobias E. Ecker,John L. Robertson,Christopher G. Rylander
Engineering 2015, Volume 1, Issue 3, Pages 344-350 doi: 10.15302/J-ENG-2015077
Convection-enhanced delivery (CED) is a promising technique leveraging pressure-driven flow to increase penetration of infused drugs into interstitial spaces. We have developed a fiberoptic microneedle device for inducing local sub-lethal hyperthermia to further improve CED drug distribution volumes, and this study seeks to quantitatively characterize this approach in agarose tissue phantoms. Infusions of dye were conducted in 0.6% (w/w) agarose tissue phantoms with isothermal conditions at 15 °C, 20 °C, 25 °C, and 30 °C. Infusion metrics were quantified using a custom shadowgraphy setup and image-processing algorithm. These data were used to build an empirical predictive temporal model of distribution volume as a function of phantom temperature. A second set of proof-of-concept experiments was conducted to evaluate a novel fiberoptic device capable of generating local photothermal heating during fluid infusion. The isothermal infusions showed a positive correlation between temperature and distribution volume, with the volume at 30 °C showing a 7-fold increase at 100 min over the 15 °C isothermal case. Infusions during photothermal heating (1064 nm at 500 mW) showed a similar effect with a 3.5-fold increase at 4 h over the control (0 mW). These results and analyses serve to provide insight into and characterization of heat-mediated enhancement of volumetric dispersal.
Keywords: near-infrared laser thermochemotherapy agarose photothermal heating micro-catheter malignant glioma
ZHU Lidong, CHEN Xiaoping
Frontiers of Medicine 2007, Volume 1, Issue 4, Pages 364-368 doi: 10.1007/s11684-007-0070-y
He Shenxu,Xiong Liulin,Yu Jinsheng,Lan Jiang
Strategic Study of CAE 1999, Volume 1, Issue 2, Pages 62-66
Keywords: malignant tumor pyrotherapy extracorporeal focused ultrasound
Yanlin Zhao,Xiao Zhong,Xiaohong Ou,Huawei Cai,Xiaoai Wu,Rui Huang
Frontiers of Medicine 2017, Volume 11, Issue 1, Pages 120-128 doi: 10.1007/s11684-017-0501-3
Norepinephrine transporter (NET) transfection leads to significant uptake of iodine-131-labeled metaiodobenzylguanidine (131I-MIBG) in non-neuroendocrine tumors. However, the use of 131I-MIBG is limited by its short retention time in target cells. To prolong the retention of 131I-MIBG in target cells, we infected hepatocarcinoma (HepG2) cells with Lentivirus-encoding human NET and vesicular monoamine transporter 2 (VMAT2) genes to obtain NET-expressing, NET-VMAT2-coexpressing, and negative-control cell lines. We evaluated the uptake and efflux of 131I-MIBG both in vitro and in vivo in mice bearing transfected tumors. NET-expressing and NET-VMAT2-coexpressing cells respectively showed 2.24 and 2.22 times higher 131I-MIBG uptake than controls. Two hours after removal of 131I-MIBG-containing medium, 25.4% efflux was observed in NET-VMAT2-coexpressing cells and 38.6% in NET-expressing cells. In vivo experiments were performed in nude mice bearing transfected tumors; results revealed that NET-VMAT2-coexpressing tumors had longer 131I-MIBG retention time than NET-expressing tumors. Meanwhile, NET-VMAT2-coexpressing and NET-expressing tumors displayed 0.54% and 0.19%, respectively, of the injected dose per gram of tissue 24 h after 131I-MIBG administration. Cotransfection of HepG2 cells with NET and VMAT2resulted in increased 131I-MIBG uptake and retention. However, the degree of increase was insufficient to be therapeutically effective in target cells.
Keywords: norepinephrine transporter vesicular monoamine transporter 2 -MIBG gene therapy lentivirus vector
Construction of 6HRE-GFAP-Baxα system specific for glioma gene therapy
TIAN Yongji, LI Guilin, GAO Jun, WANG Renzhi, KONG Yanguo, ZHANG Zhenxing, LI Shifang, TIAN Shiqiang, DOU Wanchen, ZHANG Bo
Frontiers of Medicine 2007, Volume 1, Issue 1, Pages 49-53 doi: 10.1007/s11684-007-0010-x
Keywords: GFAP-Baxα BT325 Fibrillary apoptotic specificity
JIANG Yuan, TIAN Xuehong, YUAN Jie, JIN Yuemei, TAN Yusong
Frontiers of Medicine 2007, Volume 1, Issue 4, Pages 398-400 doi: 10.1007/s11684-007-0077-4
Keywords: anticarcinogenic microvessel density malignant potency muscle uterine leiomyosarcoma
Experimental study on BPA uptake of glioma cell lines
Yang Lei,Wang Xiao,Sui Li,Kong Fuquan,Hao Xiaojuan,Zheng Jieying,Ma Nanru,Cui Suzhen,Liu Quanwei,Zhao Kui
Strategic Study of CAE 2012, Volume 14, Issue 8, Pages 85-90
Objective: to evaluate the incorporation of BPA by glioma cell lines,cells was increasing with the increasing concentration of BPA, and the boron concentration ratios of gliomaConclusion: BPA has a selectivity for glioma cells, and the results of the efflux assay confirm the temperature
Keywords: boron neutron capture therapy BPA glioma cell line ICP AES
Boron neutron capture therapy for glioblastoma of prospects and confused
Zhou Youxin,Sun Ting,Yang Weilian,Du Ziwei
Strategic Study of CAE 2012, Volume 14, Issue 8, Pages 82-84
Boron neutron capture therapy (BNCT) is a selective radiotherapy of damage tumor cells, and α particle produced by which is effective to prevent glioblastoma multiform recurrence. Clinical trails of BNCT were carried out in fifties to sixties of 20 century in developed countries, but it was limited because of the development of boron carrier and neutron source. This is a review of BNCT prospect on glioblastoma multiform.
Keywords: boron neutron capture therapy glioblastoma multiform glioma stem cells
Neutron capture therapy clinical development in the world
Zhang Zichu,Jin Congjun,Liu Kai,Zhang Guozhen,Yang Lijun
Strategic Study of CAE 2012, Volume 14, Issue 8, Pages 100-105
Keywords: BNCT GBM malignant melanoma recurent head & neck cancer metastatic liver cancer
Title Author Date Type Operation
Progress on molecular biomarkers and classification of malignant gliomas
Chuanbao Zhang, Zhaoshi Bao, Wei Zhang, Tao Jiang
Journal Article
Molecular targeted therapy of gynecological malignant tumors: the development and challenge, from laboratory
Pengming SUN PhD, MD , Jalid SEHOULI PhD, MD , Lihui WEI BM ,
Journal Article
Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma
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Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell
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RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway
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Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and
Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang
Journal Article
Characterizing Thermal Augmentation of Convection-Enhanced Drug Delivery with the Fiberoptic Microneedle Device
R. Lyle Hood,Rudy T. Andriani,Tobias E. Ecker,John L. Robertson,Christopher G. Rylander
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Change and significance of T-cell subsets and TNF-α in patients with advanced malignant obstructive jaundice
ZHU Lidong, CHEN Xiaoping
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The Preliminary Study On Malignant Tumors Effects of High Intensive Focused Ultrasound——A Primary ClinicalReport On 78 Cases of Malignant Turmors in HIFU Therapy
He Shenxu,Xiong Liulin,Yu Jinsheng,Lan Jiang
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monoamine transporter 2 genes for increased retention of metaiodobenzylguanidine labeled with iodine 131 in malignant
Yanlin Zhao,Xiao Zhong,Xiaohong Ou,Huawei Cai,Xiaoai Wu,Rui Huang
Journal Article
Construction of 6HRE-GFAP-Baxα system specific for glioma gene therapy
TIAN Yongji, LI Guilin, GAO Jun, WANG Renzhi, KONG Yanguo, ZHANG Zhenxing, LI Shifang, TIAN Shiqiang, DOU Wanchen, ZHANG Bo
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Relationship of adrenomedullin expression and microvessel density and prognosis in smooth muscle tumor of uterus
JIANG Yuan, TIAN Xuehong, YUAN Jie, JIN Yuemei, TAN Yusong
Journal Article
Experimental study on BPA uptake of glioma cell lines
Yang Lei,Wang Xiao,Sui Li,Kong Fuquan,Hao Xiaojuan,Zheng Jieying,Ma Nanru,Cui Suzhen,Liu Quanwei,Zhao Kui
Journal Article
Boron neutron capture therapy for glioblastoma of prospects and confused
Zhou Youxin,Sun Ting,Yang Weilian,Du Ziwei
Journal Article